[Netherlands] Phd Student / Post-Doc - NCMLS
Within the department of Physiology, section Cell Physiology, of the UMC St Radboud in Nijmegen, we are looking for a PhD student or post-doc m/f (2-4 years, 38 hours/week).
Within the section Cell Physiology, research is performed towards the regulation of water and ion transport in cells of organs like the kidney, intestine or brain. We are housed in the ‘Nijmegen Centre for Molecular Life Sciences (NCMLS), the new research centre of the University of Nijmegen, in which fundamental and clinical applied research are merged.
Daily we produce 180 litres of pro-urine in the kidney of which 1.5 litres is voided. The remaining 178 litres are reabsorbed. Concentration of urine in the kidney occurs through insertion and retrieval of Aquaporin-2 water channels into the apical plasma membrane, which is regulated by the antidiuretic hormone vasopressin (AVP), binding to its vasopressin type-2 receptor (V2R). AVP action is counteracted by several other hormones, which mediate internalization of AQP2 through protein kinase C (PKC). Interestingly, we found that PKC activation internalizes AQP2 through its short-chain ubiquitination and phosphorylation and that AQP2 mutants in the disease nephrogenic diabetes insipidus are extensively ubiquitinated/phosphorylated. Here, we will unravel the role of AQP2 phosphorylation/ubiquitination in health and disease and how AVP-counteracting hormones down-regulate AQP2-mediated water permeability. Additionally, it may lay the first molecular connection between renal water and salt transport.
Requirements:
- A finished university education in (medical) biology or chemistry (masters, Drs or Dr)
- Strong motivation to succeed in scientific research
- Experience in relevant Molecular and Cell Biological research
- Experience with the FRET is a pre
- Independent and well-structured working style
- Well-developed social skills directed to work in a team
We offer:
a professional and highly-motivating working environment with about 25 colleagues in a well-equipped department. The salary will be according to the CAO-RUNMC for PhD students/post-docs.
Closing date:
Until position is fulfilled
Further information, contact and sending of applications to:
Dr. Peter M.T. Deen
P.Deen@ncmls.ru.nl
31-24-3617347
http://www.physiology-nijmegen.nl
If you want to apply, please send your application, curriculum vitae and notes to
Dr Deen,
286 dept Physiology,
Radboud University Nijmegen Medical Centre,
PO Box 9101, 6500 HB Nijmegen,
The Netherlands
